MEDIZINISCHE KLINIK UND POLIKLINIK I
Gastroenterologie, Hepatologie, Infektiologie, Nephrologie, Endokrinologie, Diabetologie
UNIVERSITÄTSKLINIKUM BONN
Prof. Dr. Christian Strassburg

Wissenschaftliche Studien

Forschungslabor - Arbeitsgruppe Nephrologie / Prof. Dr. von Vietinghoff

Kontakt: Medizinische Klinik und Poliklinik I Biomedizinisches Zentrum Members: Sibylle von Vietinghoff, MD Lab manager and technician Julia Milleck, BA Postdoctoral researchers Dr. Uta Köpf Graduate students: Anne M. Hüsing, pharmacist Eva Roy-Chowdhury, MD student Nicolas Brauns, MD student

Research interest

We investigate the role and regulation of leukocytes in vascular inflammation in renal failure.

Chronic kidney disease affects a large proportion of the population. It impairs host response to pathogens but also increases atherosclerotic inflammation and mortality. Chronic inflammation of the arterial wall is a major contributor to atherosclerotic plaque growth and instability.

We investigate innate immune cells and the vascular inflammatory infiltrate in patients with chronic kidney disease and mouse models of atherosclerosis. A focus of our work has been the role of the T cell cytokine Interleukin 17 in regulation of innate immune cells (Ge et al., 2013, Dong et al, 2016, Nordlohne et al., 2018, Roy-Chowdhury et al., 2021). Current projects include translational approaches assessing vascular function and immune parameters in patients with kidney disease (Dr. Köpf).

Innate leukocytes, especially neutrophilic granulocytes and monocytes and macrophages in uremia are studied also in the kidney. For example, we have investigated kidney macrophages after transplantation and correlated their abundance with transplant survival and complications such as urinary tract infections. A recent paper addresses how B cells accumulate in the kidney in chronic disease and how this effected by longterm therapy.

Peritoneal dialysis is an important mode of renal replacement therapy. It can be a successful for years or fail due to peritoneal membrane thickening and inflammatory changes. We use our immunologic interest to better understand macrophage crosstalk with the peritoneal membrane.

In summary, we aim to improve mechanistic understanding of innate inflammation in renal impairment with the goal to define specific treatment avenues.

Our work is currently supported by
Excellence Cluster Immunosensation, Deutsche Forschungsgemeinschaft and others

Selected publications:

1. Fleig SV, Konen FF, Schröder C, Schmitz J, Gingele S, Bräsen JH, Lovric S, Schmidt BMW, Haller H, Skripuletz T, von Vietinghoff S.
Long-term B cell depletion associates with regeneration of kidney function.
Immunity, Inflammation and Disease 2021, in press.

2. Helmke A, Hüsing AM, Gaedcke S, Brauns N, Balzer MS, Reinhardt M, Hiss M, Shushakova N, de Luca D, Prinz I, Haller H, von Vietinghoff S.
Peritoneal dialysate-range hypertonic glucose promotes T cell IL-17 production that induces mesothelial inflammation.
Eur J Immunol. 2020 Sep 14. doi: 10.1002/eji.202048733.

3. Roy-Chowdhury E, Brauns N, Helmke A, Nordlohne J, Bräsen JH, Schmitz J, Volkmann J, Fleig SV, Kusche-Vihrog K, Haller H, von Vietinghoff S.
Human CD16+ monocytes promote a pro-atherosclerotic endothelial cell phenotype via CX3CR1-CX3CL1 interaction.
Cardiovascular Research 2020, Jul 27:cvaa234. doi: 10.1093/cvr/cvaa234.

4. Helmke A*, Nordlohne J*, Balzer MS, Dong L, Rong S, Hiss M, Shushakova N, Haller H, von Vietinghoff, S.
CX3CL1-CX3CR1 interaction mediates macrophage-mesothelial crosstalk that promotes peritoneal fibrosis in vivo.
Kidney international in press 2019, https://doi.org/10.1016/j.kint.2018.12.030.

5. Helmke A, Casper J, Nordlohne J, David S, Haller H, Zeisberg E, von Vietinghoff S.
Endothelial-to-mesenchymal transition shapes the atherosclerotic plaque and modulates macrophage function.
FASEB J. 2019 Feb;33(2):2278-2289.

6. Casper J*, Schmitz J*, Bräsen JH, Khalifa A, Schmidt BMW, Einecke G, Haller H, von Vietinghoff S.
Renal transplant recipients receiving loop diuretic therapy have increased urinary tract infection rate and altered medullary macrophage polarization marker expression.
Kidney International 2018 Nov;94(5):993-1001.

7. Nordlohne J, Helmke A, Ge S, Rong S, Chen R, Waisman A, Haller H, von Vietinghoff, S.
Aggravated atherosclerosis and vascular inflammation with reduced kidney function depend on Interleukin-17 eceptor A and are normalized by inhibition of IL-17A.
JACC Basic to translational Science Jan 2018 https://doi.org/10.1016/j.jacbts.2017.08.005

8. Bräsen JH, Khalifa A, Schmitz J, Dai W, Einecke G, Schwarz A, Hallensleben M, Schmidt BMW, Kreipe HH, Haller H, von Vietinghoff S.
Macrophage density in early surveillance biopsies predicts future renal transplant function.
Kidney international 2017 Aug;92(2):479-489.

9. Dong L*, Nordlohne J*, Ge S, Hertel B, Melk A, Rong S, Haller H, von Vietinghoff S.
T Cell CX3CR1 Mediates Excess Atherosclerotic Inflammation in Renal Impairment.
J Am Soc Nephrol. 2016 Jun;27(6):1753-64.

10. Ge S, Hertel B, Koltsova EK, Sörensen-Zender I, Kielstein JT, Ley K, Haller H, von Vietinghoff S.
Increased atherosclerotic lesion formation and vascular leukocyte accumulation in renal impairment are mediated by Interleukin 17A.
Circ Res. 2013 Sep 27;113(8):965-74.

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