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MEDIZINISCHE KLINIK UND POLIKLINIK I |
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Wissenschaftliche StudienForschungslabor - Arbeitsgruppe PD Dr. Langhans |
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Forschungsschwerpunkte und Projekte:
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2016 - 2019 |
Deutsche Zentrum für Infektionsforschung DZIF |
2015 - 2016 |
Doktor Pfleger-Stiftung |
2006 - 2015 |
DFG Sachmittelbeihilfe |
2003 - 2005 |
Lise-Meitner-Habilitationsprogramm des Landes NRW |
PD Dr. med. M. Gonzalez-Carmona, Ambulanz für Onkologische Gastroenterologie, CIO, UKB
Prof Dr. I. Schmidt-Wolf, CIO, UKB
PD Dr. med. S. Manekeller, Chirurgische Klinik, UKB
Prof. Dr. A. Hörauf / Dr. rer. nat. L. Layland, Institut für Medizinische Mikrobiologie, Immunologie und Parasitologie, UKB
Prof. Dr. Florian Klein, Klinik I für Innere Medizin, Universitätsklinik Köln
Prof. Dr. T. Pietschmann, Helmholtz-Zentrum für Infektionsforschung, Hannover
Prof. Dr. J. Schultze, Abteilung Genomics and Immunoregulation, LIMES Institut, Universität Bonn
Langhans B, Spengler U. Reply to: "In HIV/HCV co-infected patients T regulatory and myeloid derived suppressor cells persist after successful treatment with directly acting antivirals". J Hepatol. 2017 Aug;67(2):424-425.
Langhans B, Nischalke HD, Krämer B, Hausen A, Dold L, van Heteren P, Hüneburg R, Nattermann J, Strassburg CP, Spengler U. Increased peripheral CD4+ regulatory T cells persist after successful direct-acting antiviral treatment of chronic hepatitis C. J Hepatol. 2017 May;66(5):888-896
Lutz P, Krämer B, Kaczmarek DJ, Hübner MP, Langhans B, Appenrodt B, Lammert F, Nattermann J, Hoerauf A, Strassburg CP, Spengler U, Nischalke HD. A variant in the nuclear dot protein 52kDa gene increases the risk for spontaneous bacterial peritonitis in patients with alcoholic liver cirrhosis. Dig Liver Dis. 2016 Jan;48(1):62-8.
Langhans B, Alwan AW, Krämer B, Glässner A, Lutz P, Strassburg CP, Nattermann J, Spengler U. Regulatory CD4+ T cells modulate the interaction between NK cells and hepatic stellate cells by acting on either cell type. J Hepatol. 2015 Feb;62(2):398-404.
Lutz P, Berger C, Langhans B, Grünhage F, Appenrodt B, Nattermann J, Lammert F, Hoerauf A, Sauerbruch T, Strassburg CP, Spengler U, Nischalke HD. A farnesoid X receptor polymorphism predisposes to spontaneous bacterial peritonitis. Dig Liver Dis. 2014 Nov;46(11):1047-50.
Nischalke HD, Berger C, Lutz P, Langhans B, Wolter F, Eisenhardt M, Krämer B, Kokordelis P, Glässner A, Müller T, Rosendahl J, Fischer J, Berg T, Grünhage F, Leifeld L, Soyka M, Nattermann J, Sauerbruch T, Stickel F, Spengler U. Influence of the CXCL1 rs4074 A allele on alcohol induced cirrhosis and HCC in patients of European descent. PLoS One. 2013 Nov 18;8(11):e80848.
Langhans B, Spengler U.Reply to: "Controversy on the role of Foxp3? regulatory T cells in fibrogenesis in chronic hepatitis C virus infections". J Hepatol. 2014 Jan;60(1):232-4.
Langhans B, Krämer B, Louis M, Nischalke HD, Hüneburg R, Staratschek-Jox A, Odenthal M, Manekeller S, Schepke M, Kalff J, Fischer HP, Schultze JL, Spengler U. Intrahepatic IL-8 producing Foxp3?CD4? regulatory T cells and fibrogenesis in chronic hepatitis C. J Hepatol. 2013 Aug;59(2):229-35.
Langhans B, Nischalke HD, Arndt S, Braunschweiger I, Nattermann J, Sauerbruch T, Spengler U. Ribavirin exerts differential effects on functions of Cd4+ Th1, Th2, and regulatory T cell clones in hepatitis C. PLoS One. 2012;7(7):e42094.
Coenen M, Nischalke HD, Krämer B, Langhans B, Glässner A, Schulte D, Körner C, Sauerbruch T, Nattermann J, Spengler U. Hepatitis C virus core protein induces fibrogenic actions of hepatic stellate cells via toll-like receptor 2. Lab Invest. 2011 Sep;91(9):1375-82.
Langhans B, Kupfer B, Braunschweiger I, Arndt S, Schulte W, Nischalke HD, Nattermann J, Oldenburg J, Sauerbruch T, Spengler U. Interferon-lambda serum levels in hepatitis C. J Hepatol. 2011 May;54(5):859-65.
Langhans B, Braunschweiger I, Arndt S, Schulte W, Satoguina J, Layland LE, Vidovic N, Hoerauf A, Oldenburg J, Sauerbruch T, Spengler U. Core-specific adaptive regulatory T-cells in different outcomes of hepatitis C. Clin Sci (Lond). 2010 Apr 20;119(2):97-109.
Krämer B, Schulte D, Körner C, Zwank C, Hartmann A, Michalk M, Söhne J, Langhans B, Nischalke HD, Coenen M, Möhl C, Vogt A, Hennenberg M, Sauerbruch T, Spengler U, Nattermann J. Regulation of NK cell trafficking by CD81. Eur J Immunol. 2009 Dec;39(12):3447-58.
Schulte D, Vogel M, Langhans B, Krämer B, Körner C, Nischalke HD, Steinberg V, Michalk M, Berg T, Rockstroh JK, Sauerbruch T, Spengler U, Nattermann J. The HLA-E(R)/HLA-E(R) genotype affects the natural course of hepatitis C virus (HCV) infection and is associated with HLA-E-restricted recognition of an HCV-derived peptide by interferon-gamma-secreting human CD8(+) T cells. J Infect Dis. 2009 Nov 1;200(9):1397-401.
Klotz L, Burgdorf S, Dani I, Saijo K, Flossdorf J, Hucke S, Alferink J, Nowak N, Beyer M, Mayer G, Langhans B, Klockgether T, Waisman A, Eberl G, Schultze J, Famulok M, Kolanus W, Glass C, Kurts C, Knolle PA. The nuclear receptor PPAR gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity. J Exp Med. 2009 Sep 28;206(10):2079-89.
Nattermann J, Zimmermann H, Iwan A, von Lilienfeld-Toal M, Leifeld L, Nischalke HD, Langhans B, Sauerbruch T, Spengler U. Hepatitis C virus E2 and CD81 interaction may be associated with altered trafficking of dendritic cells in chronic hepatitis C. Hepatology. 2006; 44:945-54.
Langhans B, Braunschweiger I, Nischalke HD, Nattermann J, Sauerbruch S, Spengler U.
Presentation of the HCV-derived lipopeptide LP20-44 by dendritic cells enhances function of in vitro-generated CD4+ T cells via up-regulation of TLR2.
Vaccine. 2006; 24:3066-75.
Nattermann J, Feldmann G, Ahlenstiel G, Langhans B, Sauerbruch T, Spengler U. Surface expression and cytolytic function of natural killer cell receptors is altered in chronic hepatitis C. Gut. 2006; 55:869-77.
Langhans B, Ahrendt M, Nattermann J, Sauerbruch T, Spengler U. Comparative study of NK cell-mediated cytotoxicity using radioactive and flow cytometric cytotoxicity assays. J Immunol Methods. 2005; 306:161-8.
Langhans B, Schweitzer S, Braunschweiger I, Schulz M, Sauerbruch T, Spengler U. Cytotoxic capacity of hepatitis C virus (HCV)--specific lymphocytes after in vitro immunization with HCV-derived lipopeptides. Cytometry A. 2005; 65:59-68.
Nattermann J, Schneiders AM, Leifeld L, Langhans B, Schulz M, Inchauspe G, Matz B, Brackmann HH, Houghton M, Sauerbruch T, Spengler U.. Serum antibodies against the hepatitis C virus E2 protein mediate antibody-dependent cellular cytotoxicity (ADCC). J Hepatol. 2005; 42:499-504.
Langhans B, Braunschweiger I, Schweitzer S, Sauerbruch T, Spengler U. Primary immunisation of hepatitis C virus (HCV)-specific antibody producing B cells by lipidated peptides. Vaccine. 2004; 22:1441-7.
Langhans B, Schweitzer S, Nischalke HD, Braunschweiger I, Sauerbruch T, Spengler U. Hepatitis C virus-derived lipopeptides differentially induce epitope-specific immune responses in vitro. J Infect Dis. 2004; 189:248-53.
Langhans B, Braunschweiger I, Schweitzer S, Jung G, Inchauspe G, Sauerbruch T, Spengler U. Lipidation of T helper sequences from hepatitis C virus core significantly enhances T-cell activity in vitro. Immunology. 2001; 102:460-5.
Schweitzer S, Schneiders AM, Langhans B, Kraas W, Jung G, Vidalin O, Inchauspe G, Sauerbruch T, Spengler U. Flow cytometric analysis of peptide binding to major histocampatibility complex class I for hepatitis C virus core T-cell epitopes. Cytometry. 2000; 41:271-8.
Langhans, B, M. Lechmann, H. Ihlenfeldt, G. Jung, G. Giers, S. Schweitzer, M. El Bakri, T. Sauerbruch, and U. Spengler. A hepatitis C virus (HCV) core protein derived peptide inhibits HCV specific lymphocyte proliferation. Eur J Med Res. 2000; 5:115-20.
Lechmann M, Woitas RP, Langhans B, Kaiser K, Ihlenfeldt HG. Jung G, Sauerbruch T, Spengler U. Decreased frequency of HCV core-specific peripheral blood mononuclear cells with type 1 cytokine secretion in chronic hepatitis C. J Hepatol. 1999; 31:971-8.
Spengler U, Lechmann M, Irrgang B, Dumoulin FL, Sauerbruch T. Immune responses in hepatitis C virus infection. J Hepatol. 1996; 24:20.
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